The effect of liquiritin on the cardiotonic action of aconitine
Zhang Shuofeng Department of Chinese Herbal Pharmacology
Beijing University of Chinese Medicine
China
Abstract:
AIM In this study, the effect of liquiritin and aconitine strengthening the heart function were investigated. METHODS The effect of different dosage liquiritin was observed on aconitine strengthening the heart function of heart failure rats induced by nimodipine. Langendorff perfusion isolated rat heart was subjected to observe the effect of liquiritin on aconitine affecting the heart function. RESULTS The result indicated that with the increasing of dose, liquiritin, aconitine, and liquiritin + aconitine could obviously strengthen the cardiac muscle shrinks performance which showed as +dp/dtmax, Vmax, Vpm, LVDP, LVSP obviously rising. They could suppress the reducing of RPP, LVDP and the extension of intersystolic period on the model animal. Liquiritin administrated in advance could suppress the increasing of HR caused by aconitine. The strengthening heart function of liquiritin 3mg.kg-1 and that of aconitine was in coordination. The study of the heart function in isolated rat heart showed: The liquiritin at the speed of 80µg/h could strengthen the function of aconitine raising +dp/dtmax and -dp/dtmax by 73.8% and 160.4 %. The effect strength of aconitine was increased and the effect time of aconitine was prolonged by liquiritin. CONCLUSION: Aconitine and liquiritin could improve cardiac muscle shrink function, increase the HR and myocardium oxygen consumption, and the cardiotonic action of liquiritin was in coordination with aconitine.
